JPH0564141B2 - - Google Patents

Info

Publication number
JPH0564141B2
JPH0564141B2 JP58235863A JP23586383A JPH0564141B2 JP H0564141 B2 JPH0564141 B2 JP H0564141B2 JP 58235863 A JP58235863 A JP 58235863A JP 23586383 A JP23586383 A JP 23586383A JP H0564141 B2 JPH0564141 B2 JP H0564141B2
Authority
JP
Japan
Prior art keywords
reaction
compound
acid
group
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58235863A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60126270A (ja
Inventor
Michiaki Tominaga
Hidenori Ogawa
Takafumi Fujioka
Nagao Yo
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP58235863A priority Critical patent/JPS60126270A/ja
Priority to US06/679,632 priority patent/US4593035A/en
Priority to EP84115170A priority patent/EP0145010B1/en
Priority to DE8484115170T priority patent/DE3481611D1/de
Publication of JPS60126270A publication Critical patent/JPS60126270A/ja
Publication of JPH0564141B2 publication Critical patent/JPH0564141B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
JP58235863A 1983-12-14 1983-12-14 カルボスチリル誘導体 Granted JPS60126270A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP58235863A JPS60126270A (ja) 1983-12-14 1983-12-14 カルボスチリル誘導体
US06/679,632 US4593035A (en) 1983-12-14 1984-12-10 Carbostyril derivatives
EP84115170A EP0145010B1 (en) 1983-12-14 1984-12-11 Carbostyril derivatives
DE8484115170T DE3481611D1 (de) 1983-12-14 1984-12-11 Carbostyrilderivate.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58235863A JPS60126270A (ja) 1983-12-14 1983-12-14 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
JPS60126270A JPS60126270A (ja) 1985-07-05
JPH0564141B2 true JPH0564141B2 (en]) 1993-09-14

Family

ID=16992361

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58235863A Granted JPS60126270A (ja) 1983-12-14 1983-12-14 カルボスチリル誘導体

Country Status (4)

Country Link
US (1) US4593035A (en])
EP (1) EP0145010B1 (en])
JP (1) JPS60126270A (en])
DE (1) DE3481611D1 (en])

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803162A (en) * 1984-05-15 1989-02-07 Fluorodiagnostic Limited Partners Composition, article and process for detecting a microorganism
JPS61145162A (ja) * 1984-12-19 1986-07-02 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
JP2576862B2 (ja) * 1986-03-05 1997-01-29 大塚製薬 株式会社 カルボスチリル誘導体
US5358949A (en) * 1986-03-05 1994-10-25 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof and anti-arrhythmic agents containing the carbostyril derivatives
JPS63301821A (ja) * 1986-03-05 1988-12-08 Otsuka Pharmaceut Co Ltd 抗不整脈剤
DK111387A (da) * 1986-03-05 1987-09-06 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, laegemiddel indeholdende saadanne derivater samt fremgangsmaade til fremstilling af derivaterne
JPS63225357A (ja) * 1987-03-12 1988-09-20 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
GB8820174D0 (en) * 1988-08-25 1988-09-28 Wellcome Found Quinoline compound
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
US5319205A (en) * 1992-11-27 1994-06-07 Trionix Research Laboratory, Inc. Proximity sensor for gamma camera
WO2019043208A1 (en) 2017-09-04 2019-03-07 F. Hoffmann-La Roche Ag DIHYDROQUINOLINONES
JP7613743B2 (ja) * 2018-07-31 2025-01-15 ザ、トラスティーズ オブ プリンストン ユニバーシティ 転移性癌および化学療法抵抗性癌の治療のためのテトラヒドロキノリノ誘導体
AU2022262654A1 (en) 2021-04-22 2023-10-19 Kayothera Inc. Heterocyclic compounds and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5811947B2 (ja) * 1976-12-10 1983-03-05 大塚製薬株式会社 カルボスチリル誘導体
JPS5649364A (en) * 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5777676A (en) * 1980-10-31 1982-05-15 Otsuka Pharmaceut Co Ltd Carbostyril derivative
JPS5883677A (ja) * 1981-11-11 1983-05-19 Otsuka Pharmaceut Co Ltd カルボスチリル誘導体

Also Published As

Publication number Publication date
US4593035A (en) 1986-06-03
EP0145010A2 (en) 1985-06-19
EP0145010B1 (en) 1990-03-14
EP0145010A3 (en) 1986-04-09
JPS60126270A (ja) 1985-07-05
DE3481611D1 (de) 1990-04-19

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